Friday 26 September 2014

IN VITRO ANTIOXIDANT STATUS AND IN VIVO AMELIORATION PROPERTY OF CLITORIA TERNATA LINN. ON CARBON TETRACHLORIDE INDUCED HEPATOTOXIC OXIDATIVE STRESS IN RATS

Authors Name:  Dadi Bhaskara Rao*, Mohana Krishna. G, Raghava Rao K.V., Ravi Kiran C.H., Raghava Rao. T
Volume No : 3,  Issue No : 2,  Published year : 2014, Category : Biological Sciences

Abstract:
This study investigated the potential protective effects of Clitoria ternata by evaluating the in vitro antioxidant status as well as the in vivo amelioration of haematological parameters on CCl4 induced oxidative stress with a view to enumerate the potential areas of the utilization in the chemical and pharmaceutical industries. The present study involves the preparation of petroleum ether and chloroform leaf extracts by Soxhlet extraction process. These extracts were analyzed for their antioxidant properties such as vitamin C and antioxidant ability assays like reducing power assay, hydroxy radical scavenging assay and inhibition of in vitro lipid peroxidation. Our results were compared with standard antioxidant BHT. Furthermore, amelioration property of haematological parameters was investigated on CCl4 induced hepatotoxic oxidative stress in rats. The results showed that both PE and CE Clitoria ternata possess significant levels of vitamin C and exhibited in vitro antioxidant propertiesThis study gives an impression that Clitoria ternata could be potential candidate demonstrating the protective activity in oxidative stress.

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