Author Name: *LÓPEZ-PAZOS S.A., PORTELA D-D., RODRÍGUEZ S., CHAPARRO-GIRALDO A
Volume No : 5, Issue No : 3, Published year : 2013, Category : Biological Sciences
Abstract:
Bacillus thuringiensis has been used as an important option in the management of pest insects. Cry protein appears to be the most noteworthy virulence factor codified into the B. thuringiensis genome. Cry protein mechanism involves proteolytic activation, binding to specific receptors, pore formation and cell lysis. Cadherin-like receptor plays a major role in the Cry protein binding to the midgut epithelial cells of the pest. Cadherin has a high potential for enhancement of the lethality of Cry toxins in genetically modified (GM) crops. Cry-Cadherin GM crops have not yet been developed. All GM crops should be assessed for potential allergenicity and toxicity (among other biosafety factors) as part of a coordinated approach to worldwide safety estimation. We prospectively assessed the possible safety risk in relation to insect cadherin gene expression in GM crops. Bioinformatic analyses (sequence identity of amino acids and homology) showed that cadherin gene is not hazardous to human health in association to allergenicity and toxicity. However, the results showed that cadherins have association with desmoglein-1, a protein related to autoallergy in humans, and RTX toxin from V. cholera. For this reason, it is necessary that cadherin-expressing GM crops must undergo a complete safety evaluation.
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