Authors: *RAKESH N,1 NAGESH
K.S,2 ASHA R IYENGAR,3 DEEPA B PATIL4
ABSTRACT
Oral carcinogenesis is a
molecular and histological multistage process featuring genetic and phenotypic
markers for each stage, which involves enhanced function of several oncogenes
and/or the deactivation of tumor suppressor genes, resulting in the loss of
cell cycle checkpoints. And even oral potentially malignant disorders (OPMDs)
have the potential to transform into oral cancers. It becomes essential to
determine the severity of the disease process at an early stage. This led to
the invention of determination of various tumor markers associated with the
cancer initiation and progression so that early diagnosis and prompt treatment
can be rendered to the population at risk. Inflammation is one of the most
common finding in almost all disease scenario hence investigators have tried
utmost to find out the connecting link between inflammation and cancer. In this
paper we are highlighting on COX-2, proinflammatory mediator released in
inflammation which has been proved to have a role in carcinogenesis in human
beings.
Key Words: Oral Cancer,
Inflammation, COX-2, Potentially malignant disorders,
RT-PCR, Comet assay, DNA
damage, Reactive oxygen species
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